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Proses deteksi ini dimulai ketika sistem kekebalan mengenali epitop pada antigen. Epitop adalah subregion kecil pada antigen yang mensimulasikan pengenalan kekebalan.Jika itu adalah antigen virus, antigen akan terikat dengan protein MHC I dan disajikan oleh sel antigen-presenting ke sel CD8 yang kemungkinan akan memicu imunitas seluler.Bakteri yang